Difopein TFA (396834-58-5 free base) ( —— )

产品货号. M30250 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Difopein TFA (396834-58-5 free base)
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells.
产品描述

Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells.
同义词

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通路

Others
靶点

Other Targets
受体

14-3-3 protein
研究领域

——
适应症

——

CAS Number

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分子量

6501.2
分子式

C275H425N76F3O91S6
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

Sequence:{Ser}{Ala}{Asp}{Gly}{Ala}{Pro}{His}{Cys}{Val}{Pro}{Arg}{Asp}{Leu}{Ser}{Trp}{Leu}{Asp}{Leu}{Glu}{Ala}{Asn}{Met}{Cys}{Leu}{Pro}{Gly}{Ala}{Ala}{Gly}{Leu}{Asp}{Ser}{Ala}{Asp}{Gly}{Ala}{Pro}{His}{Cys}{Val}{Pro}{Arg}{Asp}{Leu}{Ser}{Trp}{Leu}{Asp}{Leu}{Glu}{Ala}{Asn}{Met}{Cys}{Leu}{Pro}{Gly}{Ala}{Ala}{Gly}{Leu}{Glu}

Masters SC, et al. 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem. 2001 Nov 30;276(48):45193-200. Epub 2001 Sep 27.

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